The RN Comandante Margottini is one of the Comandanti Medaglie d'Oro class of destroyers, the most modern Italian World War II destroyer design incorporating lessons learned by the Regia Marina during the war. She and the rest of her class were laid down but never completed, thus the Margottini is present in the game in her planned configuration. She features heavier main guns than previous Italian destroyers, much improved anti-aircraft armament, and even an air-search radar.

Introduced in Update "Raining Fire", RN Comandante Margottini is a destroyer with good speed and manoeuvrability perfect to dodge enemy salvos and torpedoes. For armament, the Margottini has a standard armament of four main cannons and one of the best AA armaments to use against enemy boats and planes. As additional armament, she can carry six torpedoes divided between 2 torpedo launchers. However, she has a poor survivability due to the relatively unprotected ammoracks, so avoid being hit in these areas by enemy ships.